Vilazodone is an antidepressant medication primarily used in the treatment of major depressive disorder (MDD), marketed under the brand name Viibryd. It functions as a selective serotonin reuptake inhibitor (SSRI) and a partial agonist of the 5-HT1A receptor, offering both mood-lifting and anxiolytic effects. Unlike traditional SSRIs, Vilazodone’s dual mechanism may result in a faster onset of action and improved tolerability. Maintaining the pharmaceutical purity of Vilazodone is essential to ensure patient safety, therapeutic effectiveness, and adherence to regulatory standards. Impurity profiling is crucial to detect and control any unwanted substances generated during manufacturing, storage, or degradation. Here are some of its known impurities listed below.
5-[4-[4-(5-Cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-benzofurancarboxamide
4-(5-Cyano-1H-indol-3-yl)butanoyl chloride
5-[4-[4-(5-Cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-benzofurancarboxylic acid
5-[4-[4-(5-Cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-benzofurancarboxylic acid ethyl ester
3-(4-(4-(Benzofuran-5-yl)piperazin-1-yl)butyl)-1H-indole-5-carbonitrile dihydrochloride ;
5-[4-[4-(5-Cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-benzofurancarboxamide HCl
Ethyl 5-(piperazin-1-yl)benzofuran-2-carboxylate
Ethyl 5-(piperazin-1-yl)benzofuran-2-carboxylate hydrochloride
N-5-(2-Carbamoyl) benzofuranyl vilazodone
5-[4-[4-(5-Cyano-1H-indol-3-yl)butyl]-4-oxido-1-piperazinyl]-2-benzofurancarboxamide