Nifedipine Impurities

Nifedipine is a calcium channel blocker commonly used in the management of hypertension and angina, marketed under various brand names such as Adalat and Procardia. It works by relaxing blood vessels and improving blood flow, thereby reducing blood pressure and cardiac workload. Ensuring the pharmaceutical purity of Nifedipine is essential for maintaining its therapeutic effectiveness, minimizing adverse effects, and meeting regulatory standards. Impurity profiling plays a key role in detecting and controlling unwanted substances that may form during manufacturing, storage, or degradation. Here are some of its known impurities listed below.

Nifedipine

Catalogue No : NIFE-OCL-001

CAS No : 21829-25-4

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Synonyms
Dimethyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate

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Nifedipine Dehydro Hydroxy Lactone

Catalogue No : NIFE-OCL-002

CAS No : 34785-00-7

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Synonyms
Methyl 2-methyl-4-(2-nitrophenyl)-5-oxo-5,7-dihydrofuro[3,4-b]pyridine-3-carboxylate

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Nifedipine Dehydro Hydroxymethyl Carboxylate

Catalogue No : NIFE-OCL-003

CAS No : 34783-31-8

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Synonyms
2-(Hydroxymethyl)-5-(methoxycarbonyl)-6-methyl-4-(2-nitrophenyl)nicotinic acid

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Nifedipine Dehydro N-Oxide

Catalogue No : NIFE-OCL-004

CAS No : 88434-69-9

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Synonyms
2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid 3,5-dimethyl ester 1-oxide

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Nifedipine EP Impurity C

Catalogue No : NIFE-OCL-005

CAS No : 39562-27-1

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Synonyms
Methyl 2-(2-nitrobenzylidene)-3-oxobutanoate

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Nifedipine EP Impurity D

Catalogue No : NIFE-OCL-006

CAS No : 14205-39-1

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Synonyms
Methyl 3-aminobut-2-enoate

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Nifedipine Monoamide

Catalogue No : NICA-OCL-008

CAS No : 114709-68-1

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Synonyms
Nifedipine Amide Impurity 5-(Aminocarbonyl)-1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3-pyridinecarboxylic acid methyl ester

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